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[P1–353]: CEREBRAL PERFUSION IN THE 5XFAD MOUSE MODEL OF ALZHEIMER's DISEASE
Author(s) -
DeBay Drew R.,
Phi TanTrao,
Bowen Chris V.,
Burrell Steve,
Darvesh Sultan
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.369
Subject(s) - perfusion , cerebral blood flow , medicine , neuroimaging , perfusion scanning , neuroscience , spect imaging , alzheimer's disease , pathology , positron emission tomography , cerebral perfusion pressure , disease , nuclear medicine , psychology , psychiatry
the two signals. Semi-quantitative analysis of the signal intensity in the forebrain region revealed a significant accumulation of fluorine19 MR signal in the rTg4510 mice, compared with the wild-type mice. Histological analysis showed fluorescent signals of ShigaX35 binding to the neurofibrillary tangles in the brain sections of rTg4510 mice. Conclusions: Our data indicate that fluorine-19 MRI using Shiga-X35 would be a powerful tool to evaluate the accumulation of neurofibrillary tangles in the brain.