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[P1–352]: TAU IMAGING USING FLUORINE‐19 MRI IN A MOUSE MODEL OF TAUOPATHY
Author(s) -
Yanagisawa Daijiro,
Ibrahim Nor Faeizah,
Taguchi Hiroyasu,
Morikawa Shigehiro,
Hirao Koichi,
Shirai Nobuaki,
Sogabe Takayuki,
Tooyama Ikuo
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.368
Subject(s) - tauopathy , forebrain , olfactory bulb , magnetic resonance imaging , chemistry , pathology , neuroscience , medicine , biology , central nervous system , neurodegeneration , radiology , disease
of neuroticism, extroversion, openness, agreeableness, and conscientiousness and underwent [18F]-AV-1451 tau-PET and [18F]-AV-45 b-amyloid-PET imaging. Tau levels were assessed in four regions including the amygdala, entorhinal cortex, inferior temporal cortex, and lateral occipital cortex (Figure 1), which are known to display early tau accumulation in AD. b-amyloid was examined as a composite measure from previously well-defined AD-related regions. We utilized linear regression models, adjusting for age and sex, to evaluate the association between the each of the personality traits and regional tau accumulation. Secondary analyses additionally adjusted for b-amyloid deposition. Results: Elevated neuroticism scores were significantly associated with higher tau accumulation in the amygdala (p1⁄4.003), entorhinal cortex (p1⁄4.031), and inferior temporal cortex (p<.001) (Figure 2a). In contrast, extroversion, openness, agreeableness, and conscientiousness were not associated with tau deposition for any of these regions (Figure 2b-e). After additionally adjusting for b-amyloid, results remained essentially unchanged (Table 1). Conclusions: Our results indicate that