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[P1–348]: CSF Aβ42 CONCENTRATION INDEPENDENTLY PREDICTS POSTOPERATIVE DELIRIUM IN AN ELDERLY ELECTIVE ARTHROPLASTY POPULATION
Author(s) -
Cunningham Emma L.,
McGuinness Bernadette,
Beverland David,
McAuley Daniel F.,
O'Brien Seamus,
Mawhinney Tim,
Toombs Jamie,
Zetterberg Henrik,
Schott Jonathan M.,
Lunn Michael,
Passmore Anthony Peter
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.364
Subject(s) - delirium , medicine , logistic regression , univariate analysis , cerebrospinal fluid , population , anesthesia , multivariate analysis , psychiatry , environmental health
carried out to assess the association between QoL scores and (i) depression and anxiety and (ii) Florbetapir-PET uptake with voxel-wise analyses (all age and sex adjusted). Results: There were no between group differences in QoL scores except for the physical health sub-score where SCD patients scored lower (p1⁄40.02; see Figure 1A). All QoL scores but the physical health sub-score were related to anxiety, while the physical health subscore was associated with depression (p1⁄40.003). In voxel-wise analyses, only the physical sub-score was associated with FlorbetapirPET uptake, such that worse scores predicted higher uptake in the superior and medial frontal cortex (see Figure 1B). This result remained significant after further correction for the depression score. Conclusions:The physical health sub-score of QoL, which incorporates facets of daily living activities, fatigue, pain and sleep, was affected in the SCD group and associated with Florbetapir-PET uptake in normal older adults and SCD patients independently of subclinical depression. Our results suggest that the assessment of QoL and notably of the self-perception of physical health might be relevant to preclinical AD. P1-348 CSFAb42 CONCENTRATION INDEPENDENTLY PREDICTS POSTOPERATIVE DELIRIUM IN AN ELDERLY ELECTIVE ARTHROPLASTY POPULATION Emma L. Cunningham, Bernadette McGuinness, David Beverland, Daniel F. McAuley, Seamus O’Brien, Tim Mawhinney, Jamie Toombs, Henrik Zetterberg, Jonathan M. Schott, Michael Lunn, Anthony Peter Passmore, Queen’s University Belfast, Belfast, United Kingdom; Belfast Trust, Belfast, United Kingdom; UCL Institute of Neurology, London, United Kingdom; Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M€olndal, Sweden; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; University of Gothenburg, Gothenburg, Sweden; University College London, London, United Kingdom; Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom. Contact e-mail: ecunningham03@qub.ac.uk