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[P1–346]: EFFECTS OF AEROBIC EXERCISE ON PROGRESSION OF HIPPOCAMPAL VOLUME AND COGNITION IN AMNESTIC MILD COGNITIVE IMPAIRMENT DUE TO AD
Author(s) -
Vieira de Ligo Teixeira Camila,
Ribeiro Rezende Thiago Junqueira,
Magalhães Thamires NC.,
Weiler Marina,
Flavia MKC Cassani Ana,
Queiroz de Almeida Debora,
Quinaglia AC Silva Thiago,
Giroud Joaquim Helena Passarelli,
Leme Talib Leda,
Forlenza Orestes Vicente,
Franco Mariana Pires,
Nechio Pedro Eduardo,
Fernandes Paula,
Cendes Fernando,
Figueredo Balthazar Marcio Luiz
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.362
Subject(s) - aerobic exercise , neurocognitive , dementia , hippocampus , medicine , cognition , hippocampal formation , physical therapy , treadmill , physical medicine and rehabilitation , audiology , psychology , cardiology , disease , psychiatry
anosognosia; sixteen had anosognosia for memory items, fifteen showed anosognosia for non-memory items, and ten had anosognosia for both memory and non-memory items. Pearson’s correlations showed that the total discrepancy and non-memory scores were significantly correlated with a measure of global cognitive ability (the Mini-Mental State Examination), abstract reasoning (Raven’s Progressive Matrices), constructional apraxia (i.e., Rey-Osterrieth Figure – copy) and short-term memory (Digit Span and Corsi block-tapping test). Lower GM volume in fronto-limbic areas (i.e., the anterior cingulate and medial frontal gyrus) was also found to be associated with reduced general awareness. The memory subcomponent discrepancy scores only correlated with short-term memory and global cognitive ability, and were associated with lower GM volume in fronto-limbic areas and in subcortical structures (i.e., thalamus, caudate). Conclusions:This study demonstrates that anosognosia of cognitive and functional performance in amnestic MCI patients is associated with general cognitive impairment, memory dysfunction and lower GM volume in fronto-limbic and subcortical structures. These results support recent evidence according to which these anatomical regions are involved in reduced awareness and confirm the importance to delineate and further explore anosognosia of both memory and non-memory dysfunctions.