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[P1–330]: DIFFERENTIAL INTERACTION OF APOE ε4 AND PSYCHOSIS PHENOTYPES ON COGNITIVE PERFORMANCE IN ALZHEIMER's DISEASE
Author(s) -
Qian Winnie,
Kim Julia,
Schweizer Tom A.,
Fischer Corinne E.,
Munoz David G.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.346
Subject(s) - psychosis , apolipoprotein e , delusion , psychology , cognition , disease , dementia , alzheimer's disease , psychiatry , clinical psychology , medicine
PCA. Methods: After IRB approval, three electronic surveys were launched and targeted to patients and caregivers on a PCApatient Facebook page and to physicians on a Listserv of the North American Neuro-ophthalmology Society. Surveys were designed to characterize PCA clinical histories, caregiver burden, and physician experience with PCA. RedCap was used for secure, online data collection. Results: Eighty-two surveys were completed by patients (n1⁄445) from several countries and physicians (n1⁄437). Patients reported difficulty with driving (98%), performing simple math (93%), reading (90%), writing and drawing (90%), and depth perception (90%), while decreased color vision (77%) and homonymous hemianopic visual field defects (73%) were the most common findings by Neuro-ophthalmologists. The majority of patients reported using donepezil and memantine and perceived benefits frommemantinemore than othermedications. Caregiver surveys thus far (N1⁄417) indicatemost are sole care providerswith a high degree of stress, anxiety, and depression, and a Caregiver Strain Index average of 7 indicated a high level of stress.Conclusions:PCAhas a major impact on activities associated with independent living and places a significant burden on caregivers. The majority of patients were prescribedmedications indicated for AD, and neuro-ophthalmologists reported color vision loss and homonymous visual field defects as very common. Despite inherent validity issues, social media platforms hold promise for reaching those affected by, or caring for, rare disorders such as PCA and can provide new directions for investigations. 1. Crutch SJ et al. Lancet Neurol.2012;11(2):170-8. 2. Davies W. Orphanet J Rare Dis.2016;11(1):151.