[P1–324]: SEMANTIC INTERFERENCE DEFICITS AND THEIR RELATIONSHIP WITH SLEEP‐WAKE PHENOTYPES IN ASYMPTOMATIC OFFSPRING OF LATE‐ONSET ALZHEIMER's AND ACUTE DISEASE PATIENTS | Zendy

Guinjoan Salvador Martin | Zendy; Abulafia Carolina | Zendy; Loewenstein David A. | Zendy; Villarreal Mirta | Zendy; DuarteAbritta Barbara | Zendy; Garcia Celeste | Zendy; Bär KarlJürgen | Zendy; Nemeroff Charles B. | Zendy; LadróndeGuevara Soledad | Zendy; Fiorentini Leticia | Zendy; Vigo Daniel Eduardo | Zendy

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[P1–324]: SEMANTIC INTERFERENCE DEFICITS AND THEIR RELATIONSHIP WITH SLEEP‐WAKE PHENOTYPES IN ASYMPTOMATIC OFFSPRING OF LATE‐ONSET ALZHEIMER's AND ACUTE DISEASE PATIENTS

Author(s) -

Guinjoan Salvador Martin,

Abulafia Carolina,

Loewenstein David A.,

Villarreal Mirta,

DuarteAbritta Barbara,

Garcia Celeste,

Bär KarlJürgen,

Nemeroff Charles B.,

LadróndeGuevara Soledad,

Fiorentini Leticia,

Vigo Daniel Eduardo

Publication year - 2017

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2017.06.340

Subject(s) - offspring , asymptomatic , actigraphy , circadian rhythm , psychology , medicine , hippocampus , heart rate , disease , audiology , alzheimer's disease , biomarker , cardiology , blood pressure , biology , pregnancy , genetics , biochemistry

correlated with the informant’s report for the total FrSBe (Spearman’s Rho 1⁄4 -0.701, p <0.001), for apathy (Spearman’s Rho 1⁄4 -0.644, p <0.001) and for executive functions (Spearman’s Rho 1⁄4 -0.703, p <0.001). Disinhibition did not reach a significant correlation with cognitive performance, however surprisingly; we found a significant difference between the groups for this item when comparing previous reports to cognitive decline (p1⁄40.003). Conclusions:Preliminary data suggests that there is correlation between behavioural changes related to frontal lobe functioning, cognitive decline and dementia in people with DS.

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