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[P1–324]: SEMANTIC INTERFERENCE DEFICITS AND THEIR RELATIONSHIP WITH SLEEP‐WAKE PHENOTYPES IN ASYMPTOMATIC OFFSPRING OF LATE‐ONSET ALZHEIMER's AND ACUTE DISEASE PATIENTS
Author(s) -
Guinjoan Salvador Martin,
Abulafia Carolina,
Loewenstein David A.,
Villarreal Mirta,
DuarteAbritta Barbara,
Garcia Celeste,
Bär KarlJürgen,
Nemeroff Charles B.,
LadróndeGuevara Soledad,
Fiorentini Leticia,
Vigo Daniel Eduardo
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.340
Subject(s) - offspring , asymptomatic , actigraphy , circadian rhythm , psychology , medicine , hippocampus , heart rate , disease , audiology , alzheimer's disease , biomarker , cardiology , blood pressure , biology , pregnancy , genetics , biochemistry
correlated with the informant’s report for the total FrSBe (Spearman’s Rho 1⁄4 -0.701, p <0.001), for apathy (Spearman’s Rho 1⁄4 -0.644, p <0.001) and for executive functions (Spearman’s Rho 1⁄4 -0.703, p <0.001). Disinhibition did not reach a significant correlation with cognitive performance, however surprisingly; we found a significant difference between the groups for this item when comparing previous reports to cognitive decline (p1⁄40.003). Conclusions:Preliminary data suggests that there is correlation between behavioural changes related to frontal lobe functioning, cognitive decline and dementia in people with DS.