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[P1–322]: DYSEXECUTIVE FUNCTION, DISINHIBITION AND APATHY AND THEIR CORRELATION WITH COGNITIVE DECLINE AND ALZHEIMER's DISEASE IN ADULTS WITH DOWN SYNDROME: PRELIMINARY RESULTS
Author(s) -
Fonseca Luciana Mascarenhas,
Haddad Glenda Guerra,
Mattar Guilherme,
Cristina de Oliveira Melaine,
Maria de Figueiredo Ferreira Guilhoto Laura,
Zaman Shahid,
Holland Anthony J.,
Hoexter Marcelo Queiroz,
Machado de Campos Bottino Cassio
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.338
Subject(s) - apathy , disinhibition , dementia , dysexecutive syndrome , executive dysfunction , psychology , frontotemporal dementia , cognitive decline , cognition , disease , alzheimer's disease , executive functions , clinical psychology , psychiatry , medicine , neuropsychology
MMSE and IQCODE (16item). Results:Our sample consisted of 107 patients with AD and 60 with MCI, without significant differences on age or years of education between groups (Table 1). A correlation (-0.72) was found between FAQ and MMSE scores. This result indicates that there is a moderate association with these two measures, where higher scores in the FAQ means more impairment of functional abilities and it is associated with lower scores of MMSE, which is related to a low overall cognitive performance. FAQ and IQCODE showed a more significant correlation (0.8), higher scores in both instruments (FAQ and IQCODE) indicate more impairment on each domain. This significance was not observed in bivariate group (MCI and AD) analyses, where correlation values fluctuated around -0.26 and 0.64, indicating a weak and partial correlation between the measures. Conclusions: Functional impairment and cognitive impairment were significantly correlated when we did a global correlation analysis integrating a unique group. It has been suggested that this relationship between functional and cognitive decline goes beyond a correlation; it appears to have a bidirectional influence in the development of one to the other. The stronger correlation among FAQ and IQCODE it may be due to the source of information and the fact that the IQCODE evaluates cognitive and functional aspects. The absence of a strong correlation between instruments in the analyses by group might be due to the sample size. The use of a functional scale that assesses IADL can give to clinicians an approximation of the cognitive impairment in patients that cannot be directly evaluated. Table 1 Sample description