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[P1–320]: INTERPRETATIVE PHENOMENOLOGICAL ANALYSIS OF COGNITIVE COMPLAINTS REVEALS COMMONALITIES AND DIFFERENCES BETWEEN MEMORY‐CLINIC PATIENTS, DEPRESSIVE PATIENTS, AND HEALTHY ELDERLY
Author(s) -
Miebach Lisa,
Wolfsgruber Steffen,
Frommann Ingo,
Fließbach Klaus,
Jessen Frank,
Buckley Rachel F.,
Wagner Michael
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.336
Subject(s) - complaint , cognition , psychology , clinical psychology , interpretative phenomenological analysis , thematic analysis , neurocognitive , psychiatry , qualitative research , social science , sociology , political science , law
change, and whether various caring and treatments are needed for different ApoE genotypes. Firstly, we are here focusing on the effect of ApoE polymorphism on neuropsychological domains in AD patients. Methods:186 AD participants were recruited consecutively between 2007 and 2016 from PUMCH, China. All participants received APOE genotyping, and some underwent neuropsychological tests. Executive domain includes word fluency (n1⁄433), numeric symbol (n1⁄453), digital solitaire (n1⁄458), clock drawing (n1⁄4137), copy graphics (n1⁄453), single and series motion imitation (n1⁄418). Visuospatial domain includes copy graphics (n1⁄453), Benton visual retention (n1⁄455), and block test (n1⁄440). Memory domain includes associative learning (n1⁄464), episodic memory (n1⁄452), Benton visual retention (n1⁄455) and Auditory Verbal Learning Test (AVLT) (n1⁄4100). Reasoning and judgement domain includes similarity test (n1⁄458) and calculation (n1⁄459). Data on language tests were not included here. The data were compared by Chi-square test, with other statistics ongoing. Results: Among the six genotype groups, ε2ε3 and ε3ε3 groups had a relatively worse result on digital solitaire test, and executive, reasoning and judgement domains. ApoE34 non-carriers and heterozygotes exhibited a worse performance on long delayed recall of AVLT and executive domain than ApoE34 homozygotes. On reasoning and judgement domain, ApoE34 non-carriers had the worst performance. ApoE34 non-carriers exhibited a worse result on executive domain than ApoE34 carriers.Conclusions:1. ApoE34 non-carriers have a worse performance on neuropsychological tests than ApoE34 carriers. In AD patients, ApoE 3 / 3 occupies the greatest portion owing to its widely distribution in general population. As a result, ApoE 3 / 3 genotype might devote more in neuropsychological abnormality of AD patients. The neuropsychological abnormality related to ApoE 34/ 34 might have not been covered completely so far, such as social cognition, mental behavior, or even language. 2. The loss of neuropsychological functions differs in AD patients with different ApoE genotypes, which probably calls for different caring and treatment. (Funded by The Natural Science Foundation of China (Item 81550021) and CAMS Innovation Fund for Medical Sciences (2016-I2M-1-004).)