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[P1–310]: DIFFERENCES BETWEEN MONTREAL COGNITIVE ASSESSMENT AND MINI‐MENTAL STATE EXAMINATION IN REFLECTING COGNITIVE RESERVE
Author(s) -
Kang Jae Myeong,
Lee JunYoung,
Cho YoungSung,
Park Soowon,
Sohn Bo Kyung,
Cho SeongJin,
Lee JaeHong
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.326
Subject(s) - montreal cognitive assessment , cognition , cognitive impairment , normative , mini–mental state examination , psychology , cognitive reserve , medicine , gerontology , psychiatry , political science , law
Background:Apathy is one of the most common behavioural and psychological symptoms of dementia. Prevalence of apathy in Alzheimer’s Disease (AD) is estimated to be 36% (range – 17%-82%) for individuals in nursing homes. When measured by the NPI, prevalence is 32% (range – 23%-48%). Although common, apathy continues to be under-diagnosed and under-researched. While thought to be co-morbid with depression, the literature supports apathy as a distinct clinical entity although the exact biological cause is unknown. As part of a larger ongoing international collaboration between King’s College London and University of Exeter in the UK and Innlandet Hospital Trust, Norwegian University of Science and Technology and the Norwegian National Advisory Unit on Ageing and Health in Norway, we present the apathy and depression data in a cohort of nursing home and community-based participants. Methods: Nursing home and community-based participants (n1⁄42313) with AD were assessed with the 12-item Neuropsychiatric Inventory (NPI). An NPI score of 0 represented no symptoms present. Score of each NPI subscale was calculated by multiplying severity by frequency. Participants’ characteristics, means, standard deviations (SD), Mini-Mental State Exam (MMSE), Clinical Dementia Rating (CDR) scale, NPI apathy and depression scores were analysed by descriptive statistics in SPSS. Results: For the whole cohort, mean age 6 SD was 81.6 6 7.38. 32.6% were male and 67.4% were female. The mean MMSE 6 SD was 15.6 6 7.99 and median CDR was 2. 49.3% had apathy and 46.7% had depression as measured by the NPI. Apathy occurred in 20.5% in isolation while 17.8% had depression alone. 28.0% of participants had both symptoms. Conclusions:There is a subset of people with AD that can have apathy without depression and vice versa, therefore supporting apathy as a separate clinical entity. Future work should be done to ascertain the extent of shared and unique biological correlates between the two symptoms.