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[P1–271]: A NOVEL COLORIMETRIC ELISA FOR QUANTIFICATION OF TAU, PHOSPHORYLATED AT THREONINE 181, IN CEREBROSPINAL FLUID
Author(s) -
Herbst Victor,
Brix Britta,
Busse Stefan,
Vanderstichele Hugo Marcel,
Stoops Erik
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.287
Subject(s) - cerebrospinal fluid , biomarker , medicine , chromatography , oncology , pathology , chemistry , biochemistry
(0.82, 0.68-0.99, p1⁄40.03), SAM (0.62,0.40-0.98, p1⁄40.04), cobalamin/B12 (0.90,0.81-1.0), p1⁄40.04, taurine (0.88,0.770.99, p1⁄40.04), and 5-MTHF (0.91,0.82-1.00, p1⁄40.05). Conclusions: This meta-analysis provides support for the vascular hypothesis of AD, and suggests that cardiovascular and glial mechanisms (homocysteine, 24(s)hydroxycholesterol, and YKL-40) play an important role in AD pathogenesis. Reduced perfusion due to atherosclerosis is also suggested (homocysteine and 24(s)hydroxycholersterol). Homocysteine is associated with cognitive decline and brain atrophy. It can be inferred that vitamin B supplementation, and reduction of homocysteine levels prevent cognitive loss.