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[P1–259]: PHOSPHOLIPID DISRUPTION IN THE BRAIN LINKS MOUSE MODELS OF REPETITIVE MILD TRAUMATIC BRAIN INJURY AND ALZHEIMER's DISEASE
Author(s) -
Ojo Joseph,
Algamal Moustafa,
Abdullah Laila,
Crawford Fiona,
Evans Jim E.,
Mullan Michael
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.275
Subject(s) - traumatic brain injury , hippocampus , phospholipid , arachidonic acid , sphingomyelin , medicine , pathogenesis , phosphatidylethanolamine , endocrinology , phosphatidylcholine , biology , biochemistry , cholesterol , psychiatry , membrane , enzyme
normal, mild cognitive impairment or dementia). SNAP is also a complement to the new National Institute on Aging–Alzheimer Association (NIA-AA) research criteria of preclinical AD. We aimed to explore the biomarkers in different clinical status with SNAP. Methods:We used the baseline data from Alzheimer’s Disease Neuroimaging Initiative 1 (ADNI1) and collected the individuals with SNAP (clinically normal, mild cognitive impairment or dementia). The criteria were decreased CSF Ab1-42 (<192pg/ml) and elevated CSF Tau (total Tau>93pg/ml, or phosphorylated Tau>23pg/ml). The data of biomarkers from CSF (e.g. Ab, Tau, a-synuclein, sAPPb, neurogranin, b-secretase, neurofilament, isoprostane, multiplex proteomics) and plasma (e.g. Ab, Tau, neurofilament) were extracted. Mann-Whitney U tests were carried out between the groups of different clinical status, and P<0.05 was regarded as statistical significance. Results: A total of 31 SNAP individuals were selected from ADNI1 cohort, with 18 clinically normal, 9 MCI and 4 dementia. APOE4 alleles were only 8%. In comparison with clinically normal, CSF CD40 (Mann-Whitney U test, Z1⁄42.024, P 1⁄40.046) and fibrinogen (Mann-Whitney U test, Z1⁄42.239, P 1⁄40.025) significantly changed in MCI, as well as CSF isoprostane (ISO8PGF2A) was elevated in dementia. In comparison with clinically normal, CSF isoprostane (ISO8PGF2A) (Mann-Whitney U test, Z1⁄4-2.315, P1⁄40.020) was elevated in dementia. Conclusions: APOE4 is less common in SNAP. Only elevated ISO8PGF2A is observed in dementia in comparison with clinically normal and MCI, which is not found between clinically normal and MCI. Large-sample is required to confirm our findings and seek better biomarkers to differentiate the clinical status of SNAP. As the previous opinion “SNAP individuals are stable over time”, biomarkers signature suggests SNAP may be normal aging rather than pathological changes, in which brain atrophy and cognitive decline progress slowly.