Premium
[IC‐01–04]: A ROBUST, SIMPLIFIED BRAAK‐TYPE CLASSIFICATION SCHEME FOR FLORTAUCIPIR F‐18 TAU PET IMAGES
Author(s) -
Schwarz Adam J.,
Slieker Lawrence J.,
Risacher Shan L.,
Southekal Sudeepti,
Joshi Abhinay D.,
Devous Michael D.,
Saykin Andrew J.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2624
Subject(s) - temporal lobe , entorhinal cortex , fusiform gyrus , voxel , parahippocampal gyrus , middle temporal gyrus , region of interest , inferior temporal gyrus , temporal cortex , pattern recognition (psychology) , nuclear medicine , neuroscience , artificial intelligence , medicine , hippocampus , psychology , computer science , functional magnetic resonance imaging , epilepsy
correlation between global FMM retention and brain atrophy in any groups. There were positive correlations between THK retention in the frontal, parietal, occipital cortices or precuneus and FMM retention in the frontal, parietal cortices or precuneus. EOAD had weak positive correlation between THK and FMM retention only in the occipital cortex. Conclusions: LOAD showed gradual increase in both tau and amyloid and those two pathologies have association to each other. Whereas, in EOAD, tau and amyloid may develop more abruptly and independently. Brain atrophy was associated with tau burden inEOAD, however,was not correlatedwith amyloid burden in EOAD or LOAD. These findings suggest LOAD and EOAD may have different courses of pathomechanism.