Premium
[IC‐P‐214]: OPTIMIZING COGNITIVE CHANGE INDEX CUTOFFS BASED ON COGNITIVE DECLINE AND BIOMARKER POSITIVITY IN COGNITIVELY NORMAL OLDER ADULTS
Author(s) -
Risacher Shan L.,
West John D.,
McDonald Brenna C.,
Tallman Eileen F.,
Glazier Bradley S.,
Gao Sujuan,
Brown Steve,
Apostolova Liana G.,
Brosch Jared R.,
Farlow Martin R.,
Unverzagt Frederick W.,
Saykin Andrew J.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2590
Subject(s) - cutoff , cognition , cognitive decline , episodic memory , biomarker , dementia , receiver operating characteristic , medicine , cut off , psychology , audiology , oncology , disease , psychiatry , biochemistry , chemistry , physics , power (physics) , quantum mechanics
associations between both self and informant ECog scores and [F] Flortaucipir SUVR were observed (Figure 1). Notably, the selfbased memory concerns were associated with tau load predominantly in the frontal cortex and medial temporal regions, while the informant-based concerns were more strongly associated with precuneus and lateral parietal tau load (Figure 1C). However, informant-based concerns were associated with more widespread regions than self-based concerns on voxel-wise analysis (Figure 1B). Conclusions: The association between subjective concerns and tau deposition suggests an important role of tau pathology in the early stages of disease and that involvement of different brain regions underlie the phenomena detected by the ECog scale. Future longitudinal studies will help to elucidate the timing and source of cognitive concern presentation relative to disease and pathological progression.