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[IC‐P‐212]: ANTICHOLINERGIC MEDICATION USE IS ASSOCIATED WITH REDUCED FMRI ACTIVITY DURING VISUAL EPISODIC ENCODING IN COGNITIVELY NORMAL OLDER ADULTS
Author(s) -
Risacher Shan L.,
West John D.,
McDonald Brenna C.,
Tallman Eileen F.,
Glazier Bradley S.,
Gao Sujuan,
Brown Steve,
Apostolova Liana G.,
Brosch Jared R.,
Farlow Martin R.,
Unverzagt Frederick W.,
Campbell Noll L.,
Boustani Malaz A.,
Saykin Andrew J.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2588
Subject(s) - anticholinergic , dementia , audiology , medicine , pittsburgh compound b , hippocampal formation , cognition , voxel , psychology , atrophy , physical medicine and rehabilitation , psychiatry , disease , radiology
computed type-I error of finding based on the percentage of times that VHCdecline preceded MMSE decline by a given number of years. Results: VHC and MMSE declines in progressors diverged from non-progressors 6.7 and 3.5 years before progression to probable AD dementia, respectively. Out of 500 simulations, VHCfailed to decline earlier thanMMSE scores 0 times (p<0.002); at least one year earlier 4 times (p1⁄40.008); at least 2 years earlier 23 times (p1⁄40.045), and at least 3 years earlier 85 times (p1⁄40.17). Findings remained significant with variances as high as 200%. Conclusions: The CMCS method can be used to compare the temporal sequence of different AD biomarker and cognitive changes.