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[IC‐P‐208]: AV‐1451 PET‐TAU IMAGING QUANTIFICATION AND CORRELATIONS
Author(s) -
Zhou Yongxia,
Bai Bing
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2584
Subject(s) - putamen , subiculum , nuclear medicine , temporal cortex , positron emission tomography , standardized uptake value , neuroscience , chemistry , neuroimaging , hippocampus , temporal lobe , pathology , psychology , medicine , dentate gyrus , epilepsy
and dura mater. [H]MK-6240 does not block MAO-B tracer binding in non-AD brain homogenates, but [H]AV-1451 does (Ki1⁄4 60 nM), in addition to its binding to MAO-A as previously reported. Conclusions: These results validate the expectation that MK-6240 binding in the amygdala is due to binding NFT pathology, and confirms the specificity of [H]MK-6240 binding to NFTs in human AD brains. In contrast, [H]-AV-1451 shows dis-placeable binding in regions that do not correlate with AT8 IHC staining, consistent with previous reports .