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[IC‐P‐204]: SUBJECT‐LEVEL ASSESSMENT OF REGIONAL CORRELATIONS BETWEEN TAU‐PET, AMYLOID‐PET, MRI AND FDG‐PET ACROSS THE CLINICAL SPECTRUM OF ALZHEIMER's DISEASE
Author(s) -
Whitwell Jennifer L.,
Tosakulwong Nirubol,
Weigand Stephen D.,
GraffRadford Jonathan,
Vemuri Prashanthi,
Senjem Matthew L.,
Jones David T.,
Drubach Daniel A.,
Petersen Ronald C.,
Lowe Val,
Jack Clifford R.,
Josephs Keith A.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2580
Subject(s) - pittsburgh compound b , atrophy , positron emission tomography , nuclear medicine , medicine , standardized uptake value , alzheimer's disease neuroimaging initiative , neuroimaging , pathology , amyloid (mycology) , magnetic resonance imaging , disease , grey matter , alzheimer's disease , psychology , white matter , radiology , neuroscience
[F]Florbetapir scans were read visually as positive or negative for presence of cerebral amyloid. Reference parametric mapping (RPM) with cerebellar grey matter as reference region was used to calculate [F]AV1451 binding potential (BPND). Results were analysed for 1) medial temporal lobe (MTL), known as the first region to harbour tau pathology in aging, 2) a global region (neocortex), and 3) putamen, a region thought to represent “offtarget” binding. Raw neuropsychological test scores were converted into z-scores and combined into composite scores for episodic memory. Results: [F]Florbetapir positive subjects (n1⁄47) showed higher [F]AV1451 BPND than [F]florbetapir negative subjects (n1⁄416) in MTL (0.2160.18 vs -0.0460.05, p<0.01) and neocortex (0.1460.06 vs 0.0260.04, p<0.001). Adjusted for age, sex and education, lower episodic memory scores were, although at trend level, associated with higher [F]AV1451 BPND in MTL (b1⁄4-0.52, p1⁄40.06) and neocortex (b1⁄4-0.49, p1⁄40.07), but not putamen (b1⁄4-0.25, p1⁄40.43). Across all subjects, regardless of amyloid status, higher age correlated with higher [F] AV1451 BPND in the putamen (Pearson’s r1⁄4 0.66, p<0.01), but not with [F]AV1451 BPNDin MTL and neocortex. Conclusions:These preliminary data suggest that tau load in AD specific regions of subjects with SCD is higher in amyloid positive than in amyloid negative subjects. In addition, tau accumulation in MTL and neocortex might be associated with poorer episodic memory performance. This highlights the potential of tau PET to capture early and subtle cognitive changes in subjects with SCD.