Premium
[IC‐P‐200]: INVESTIGATE THE RELATIONSHIP BETWEEN TAU AND NEUROINFLAMMATION IN ALZHEIMER's DISEASE USING PET AND REACTION RATE MODELLING
Author(s) -
Su Li,
Wang Yi,
Surendranathan Ajenthan,
BevanJones William Richard,
Passamonti Luca,
Hong Young T.,
Rodriguez Patricia Vazquez,
Mak Elijah,
Fryer Tim D.,
Aigbirhio Franklin I.,
Rowe James B.,
O'Brien John T.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2575
Subject(s) - neuroinflammation , microglia , binding potential , dementia , nuclear medicine , medicine , psychology , chemistry , pathology , neuroscience , positron emission tomography , disease , inflammation
in CBD was distinctly different from patterns in controls or patients with AD or PSP. Cortical atrophy measured with MRI was much more widespread than the cortical retention of F-AV1451 in CBD, and cortical AV-1451 uptake did not correlate with cortical thickness or glucose hypometabolism. These results were in sharp contrast to AD, where F-AV-1451 retention was more widespread than cortical atrophy and correlated well with cortical thickness and hypometabolism. Conclusions: Patients with CBD exhibited AV-1451 uptake in the motor cortex, corticospinal tract and basal ganglia contralateral to the affected body side, clearly different from controls and patients with AD or PSP. However, decreased F-Fluorodeoxyglucose (FDG) uptake and cortical atrophy, assessed with MRI, were more widespread than F-AV-1451 uptake and probably represent earlier, yet less specific, markers of pathology.