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[IC‐P‐197]: THE ASSOCIATION BETWEEN PERSONALITY AND TAU PET DEPOSITION IN COGNITIVELY NORMAL OLDER ADULTS: FINDINGS FROM THE KNIGHT ALZHEIMER DISEASE RESEARCH CENTER
Author(s) -
Schultz Stephanie A.,
Gordon Brian A.,
Mishra Shruti,
Morris John C.,
Duchek Janet M.,
Balota David A.,
Benzinger Tammie L.S.,
Ances Beau
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2572
Subject(s) - psychology , conscientiousness , entorhinal cortex , neuroticism , big five personality traits , dementia , extraversion and introversion , agreeableness , personality , clinical dementia rating , neuropathology , medicine , clinical psychology , neuroscience , disease , hippocampus , social psychology
significantly higher NTF deposition within the entorhinal cortex (p1⁄4.003), inferior temporal cortex (p1⁄4.002), amygdala (p1⁄4.004), and fusiform gyrus (p1⁄4.001) compared to controls (Figure 1). Conclusions:Our study reports patterns of NFT accumulation in pAD in not only medial temporal lobe regions, as would be expected from Braak and Braak staging, but also parietal regions predicted to be affected later in the disease. Furthermore, the regions we identified with high tau accumulation are comparable with recent studies examining tau-PET in individuals with AD dementia, suggestive of widespread cortical tau accumulation early in the disease process that intensifies with clinical onset. These results suggest that tau mediated therapies should be considered earlier in the disease course in order to prevent cognitive decline.