Premium
[IC‐P‐176]: TAU PATHOLOGY AND GRAY MATTER ATROPHY CONTRIBUTE TO COGNITIVE IMPAIRMENT IN ALZHEIMER's DISEASE
Author(s) -
Bejanin Alexandre,
Schonhaut Daniel R.,
La Joie Renaud,
Kramer Joel H.,
Baker Suzanne L.,
Sosa Natasha,
Ayakta Nagehan,
Cantwell Averill,
Janabi Mustafa,
Lauriola Mariella,
O'Neil James P.,
GornoTempini Marilu,
Miller Zachary A.,
Rosen Howard J.,
Miller Bruce L.,
Jagust William J.,
Rabinovici Gil D.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2551
Subject(s) - atrophy , cognition , psychology , neuroscience , voxel based morphometry , effects of sleep deprivation on cognitive performance , mediation , pathology , medicine , white matter , magnetic resonance imaging , radiology , political science , law
approaches produced comparable results in both cohorts, with an average quantification error close to 2% (was 2.9% in PiB). Therefore, the simpler mean atlas approach appears to be sufficient, although the PCA approach might be closer to MR quantification in the Me. Looking at the PCA decomposition, it is interesting to note that hippocampus uptake is mostly driven by spill over from the choroid plexus (CP). The CP is prominently represented in the mean image, and in the 3rd mode (5% of the variability). Uptake in the CP is therefore fairly consistent across the population, and variations in its uptake are independent from tracer retention in the Me. While not significant, there was a trend association between increasing CP uptake and increasing age in both AIBL (p1⁄40.10) and ADNI (p1⁄40.25) cohorts. Conclusions: Results show that all quantification performed using PET-only normalization approaches did equally well, with an average quantification error around 2% in both cohorts. Partial volume correctionmight however be required to account for spill over.