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[IC‐P‐175]: 18F‐AV1451 TAU QUANTIFICATION WITHOUT MRI
Author(s) -
Bourgeat Pierrick,
Villemagne Victor L.,
Dore Vincent,
Masters Colin L.,
Ames David,
Rowe Christopher C.,
Salvado Olivier,
Fripp Jurgen
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2550
Subject(s) - nuclear medicine , artificial intelligence , atlas (anatomy) , computer science , medicine , anatomy
of dysfunctional networks: anodal stimulation of the DMN (right inferior parietal lobe), cathodal stimulation of the SN (right dorsolateral prefrontal cortex). Changes from preto post-treatment in clinical scales and functional connectivity were defined as outcome measures. Outcomes from clinical scales were compared by using the Wilcoxon signed-rank test, while changes in connectivity were assessed with the Functional Connectivity Toolbox. A seed-to-voxel approach was used to assess connectivity differences between the stimulated node and the other network areas. Results:To date, 16 patients have completed the treatment. 8 patients were allocated to the anodal and 8 to the cathodal arm. Analysis of clinical-neuropsychological scores revealed a beneficial effect of anodal stimulation over cognition (Immediate recall of Rey Word Recognition test, Token test, Clock test and Semantic Fluency test; p<0.05), whereas cathodal stimulation resulted in amelioration of behavioral symptoms (Neuropsychiatric inventory; p<0.05). In the anodal arm, rsfMRI analysis revealed decreased connectivity between the stimulated parietal node and the posterior cingulate (cluster size: 142 voxels; cluster-wise FDR corrected; p<0.05) after tDCS. In the cathodal arm, no change in connectivity was detected between the stimulated node and SN nodes. Conclusions:These data suggest a different effect of the two neuromodulator paradigms over clinical and cognitive outcomes. Our results suggest that anodal tDCS may be more effective than cathodal tDCS in modulating cognition and intra-network connectivity of aberrant networks in AD. Further studies might clarify whether different paradigms or target networks could also be effective interventions in AD.