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[IC‐P‐166]: UTILITY OF PERFUSION PET MODELS AS MEASURE OF NEURODEGENERATION IN AN AUTOSOMAL DOMINANT ALZHEIMER's DISEASE POPULATION: REPORT FROM THE DIAN STUDY
Author(s) -
JosephMathurin Nelly,
Su Yi,
Blazey Tyler,
Jasielec Mateusz S.,
Vlassenko Andrei G.,
Friedrichsen Karl A.,
Gordon Brian A.,
Hornbeck Russ C.,
Cash Lisa,
Ances Beau M.,
Raichle Marcus E.,
Brickman Adam M.,
Buckles Virginia,
Cairns Nigel J.,
Cruchaga Carlos,
Fagan Anne M.,
Goate Alison,
Jack Clifford R.,
Klunk Bill E.,
Koeppe Robert A.,
Marcus Daniel S.,
Mayeux Richard,
McDade Eric,
Paumier Katrina L.,
Ringman John M.,
Saykin Andrew J.,
Thompson Paul M.,
Xiong Chengjie,
Morris John C.,
Bateman Randall J.,
Benzinger Tammie L.S.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2541
Subject(s) - precuneus , neurodegeneration , positron emission tomography , nuclear medicine , perfusion , fluorodeoxyglucose , population , brainstem , medicine , alzheimer's disease , pathology , neuroscience , psychology , disease , cognition , environmental health
Biomarkers and Lifestyle (AIBL) study of ageing. A comprehensive metric encapsulating both microscopic changes in fibre density and macroscopic changes in fibre-bundle cross-section (FDC) was obtained for each white matter fixel, and compared across groups using FBA, both at the whole-brain level, and subsequently across specific fibre tracts-of-interest. We further investigated whether changes in FDC were related to amyloid accumulation in MCI patients, by subdividing this group and comparing Ab+ (n1⁄420) and Ab(n1⁄413) MCI participants. Results:Whole-brain FBA exhibited significant FDC decreases in AD patients compared to controls, across various fibre tracts (uncinate, inferior fronto-occipital (IFOF), left arcuate fasciculi, splenium and genu) (see figure 1). When statistical analyses were limited to these fibre tracts-of-interest, MCI patients exhibited significant FDC reductions in the bilateral posterior cingulum and right uncinate fasciculus (see figure 2). When MCI patients were subdivided by Ab status, only the AbMCI group exhibited significant FDC decrease, and only in the left posterior cingulum. Conclusions:These results suggest substantial reductions in structural connectivity of various WM pathways arise in AD, and exhibit the value of FBA in identifying changes within specific fibre pathways, even in crossing fibre regions. Furthermore, while disruptions to the posterior cingulum and