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[IC‐P‐147]: HIGH SOCIAL SUPPORTS RELATE WITH LOW IN VIVO ALZHEIMER's DISEASE PATHOLOGIES IN COGNITIVELY NORMAL ELDERLY INDIVIDUALS
Author(s) -
Sung Kiyoung,
Byun Min Soo,
Yi Dahyun,
Lee Jun Ho,
Ko Kang,
Lee Seung Hoon,
Han Na Young,
Han MyeongIl,
Lee Dong Young
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2421
Subject(s) - neurodegeneration , precuneus , dementia , posterior cingulate , medicine , alzheimer's disease , psychology , disease , magnetic resonance imaging , neuroscience , cortex (anatomy) , functional magnetic resonance imaging , radiology
mecamylamine, a combination of 2.5 mg/kg scopolamine and 10 mg mecamylamine, or placebo. Working memory performance was assessed during fMRI and cholinergic challenge using the N-Back Task (NBT). Results:After E2 treatment women without SCD showed a greater increase in frontal activity during theNBT (3-back> 0-back) than women without SCD (p1⁄4 0.01, k1⁄4 200, pcorr1⁄4 0.05). During mecamylamine challenge therewas a significant three-way interaction between SCD status, E2 treatment, and task condition (F(3,480) 1⁄4 2.71, p < 0.05). Women without SCD who received E2 treatment had better 3-back performance during mecamylamine challenge than women who did not receive estradiol (t (16) 1⁄4 2.45, p<0.05: E2 d’ mean 1⁄4 2.41 SD 1⁄4 0.49; no E2 d’ mean 1⁄4 1.82, SD 1⁄4 0.53). Women with SCD who received E2 treatment had worse 3-back performance than women who did not receive E2 treatment (t (16) 1⁄4 -3.68, p<0.05: E2 d’ mean 1⁄4 2.13, SD 1⁄4 0.14; no E2 d’ mean 1⁄4 2.72, SD 1⁄4 0.14). Conclusions: In women without SCD, E2 ameliorated the effects of cholinergic blockade on memory performance. This was not seen in the SCD group. The imaging results further support E2 salutary effects on cholinergic system functioning in normal postmenopausal women but not in womenwith SCD. Postmenopausal SCDmay be amarker of cholinergic vulnerability or E2 unresponsiveness which reduces the cognitive effect of E2.