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[IC‐P‐140]: EIGHT‐YEAR LONGITUDINAL CHANGE IN CORTICAL THINNING: PROGRESSION FROM COGNITIVELY HEALTHY TO DEMENTIA
Author(s) -
Willis Sherry L.,
Kennedy Kristen M.,
Robinson Paul R.,
Rodrigue Karen M.,
Rast Philippe,
Grabowski Thomas J.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2414
Subject(s) - dementia , precuneus , longitudinal study , psychology , medicine , cardiology , audiology , neuroscience , cognition , pathology , disease
Background: Subjective cognitive decline (SCD) refers to the self-experienced worsening of the cognitive capacity in elderlies, who still perform within normal range on standardized neuropsychological tests. Episodic memory system is important for both memorizing past events, and imagination of future events, and MCI Patients showed deficits in both functions. It is unknown, whether SCD subjects show early disturbance in future imagination. Methods: 50 elderly subjects (22 SCD; 28 healthy controls, HC) underwent a semi-structured interview (free recall + structured questions) on their personal future events, and the standardized neuropsychological tests. 38 subjects participated in an fMRI experiment of a cognitive task coupled with future imagination. 42 subjects underwent a resting state fMRI measurement. Qualitative data analysis (QDA) was applied to summarize the amount of the semantic and episodic information bits of the future imagination, and subcategories (event details, perception details, place, time, and mental state) of the episodic part. Correlational analyses between the QDA scores and the fMRI first level contrasts were calculated. Results: Both groups were not different in the demographic data and neuropsychological performance. During the free recall, SCD subjects reported more event details than the HC subjects (p<0.05). No group differences during total recall were found. The activations in medial prefrontal cortex (mPFC) during future imagination were positively associated with the QDA free recall scores on semantic and episodic details in the SCD group. The QDA total score on event details was positively correlated with the connectivity strength of the parahippocampus within the default mode network (DMN) in the HC group. The QDA total scores on episodic details (event and perceptual details) were positively correlated with the connectivity strength of mPFC within the DMN in the SCD group. Conclusions: Increased free recall on event details but not in total recall in the SCD subjects, and the associations between the QDA scores irrespective of categories and the mPFC activation/connectivity, reflect the compensatory mechanism in SCD subjects. Association between the QDA score on event details and the parahippocampus connectivity in HC group supports the idea that the episodic memory system plays vital role in episodic future imagination. IC-P-140 EIGHT-YEARLONGITUDINALCHANGE IN CORTICALTHINNING: PROGRESSION FROM COGNITIVELY HEALTHY TO DEMENTIA Sherry L. Willis, Kristen M. Kennedy, Paul R. Robinson, Karen M. Rodrigue, Philippe Rast, Thomas J. Grabowski, University of Washington, Seattle, WA, USA; University of Texas at Dallas, Dallas, TX, USA; University of California, Davis, Davis, CA, USA; University of Washington Medical Center, Seattle, WA, USA. Contact e-mail: kmk082000@utdallas.edu