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[IC‐P‐138]: CORTICAL THINNING PATTERN IN AUTOSOMAL DOMINANT AD PREDICTS AMYLOID POSITIVITY IN SPORADIC AD
Author(s) -
HariRaj Amrita,
Dincer Aylin,
Gordon Brian A.,
Su Yi,
Ances Beau M.,
Morris John C.,
Bateman Randall J.,
Benzinger Tammie L.S.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2412
Subject(s) - clinical dementia rating , atrophy , dementia , medicine , amyloid (mycology) , pathology , pittsburgh compound b , disease , neuroscience , cardiology , psychology
sequences. Whole brain structure is assessed with T1-weighted inversion recovery and 3D FLAIR images. Higher spatial resolution images are acquired over a limited field of view centered on the hippocampus. T2*-weighted images are acquired for assessment of cerebral microbleeds. Arterial spin labeling (ASL) images are acquired via 3D pCASL, 2D PASL or 3D PASL sequences, depending on availability.The protocols diverge for resting state fMRI and diffusion imaging. The bifurcation is driven largely by the availability of simultaneous multi-slice (SMS) accelerated imaging. Diffusion imaging is done using a single b1⁄41000 s/mmshell in the basic protocol and with three shells (b1⁄4500, 1000 and 2000 s/mm) in the advanced protocol. Resting state data are acquired with TR w600 ms in the advanced protocol and 3000 ms in the basic protocol. Results:The breakdown of scanner manufacturers and models for the 57 scanners is shown in Table 2. The commercial availability of SMS in the U.S. is new and still increasing; initially all scanners have been outfitted with the basic protocol. As scanners are upgraded, it is estimated that approximately 30-45% of scanners upgrade to an advanced protocol by 2019. Conclusions: ADNI-3 data will be collected using basic and advanced protocols. Structural imaging is implemented consistently across the protocols.