Premium
[IC‐P‐129]: DIAGNOSTIC UTILITY OF FDG‐PET IN DETECTING EARLY SIGNS OF NEURODEGENERATION IN ASYMPTOMATIC SUBJECTS WITH FAMILIAL FORMS OF AD
Author(s) -
Boccardi Marina,
Altomare Daniele,
Festari Cristina,
Drzezga Alexander,
Frisoni Giovanni B.,
Nobili Flavio
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2403
Subject(s) - asymptomatic , medicine , presenilin , context (archaeology) , gold standard (test) , precuneus , disease , oncology , alzheimer's disease , psychiatry , biology , paleontology , cognition
age1⁄466.4 years; 56% female; equal % Black/Hispanic/non-Hispanic White) underwent 3T MRI. mcDESPOT quantified ‘restricted’ water trapped within the lipid bilayers of myelin sheath, providing a measure of myelin water fraction (MWF). Regardless of medication status, systolic blood pressure (SBP) was determined via two readings separated by 5-minute intervals; blood glucose was measured by fasting levels of hemoglobin A1c. Separate ageadjusted linear regressions investigated the associations between SBP and A1c on whole-brain MWF. Analyses were fully corrected for multiple comparisons and utilized threshold-free cluster enhancement. Results: Higher SBP was associated with lower MWF within deep white matter and parietal regions (p<.05), whereas greater A1c was associated with lower MWF in deep white matter and more temporal regions (p<.05; see Figure 1a). Similar associations were noted in a subset of fifteen Hispanics at increased risk for uncontrolled CVD-RFs (see Figure 1b). Conclusions: Higher levels of SBP and A1c are associated with decreased myelin integrity in a sample of older, ethnically diverse adults. These results suggest that mcDESPOT may be a useful tool to detect the adverse effects of CVD-RFs on white matter integrity in and around areas of WMH in older non-demented/non-depressed adults.