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[IC‐P‐123]: ATROPHY OF THE POSTERIOR SUBICULUM IS ASSOCIATED WITH MEMORY IMPAIRMENT, TAU AND Aβ PATHOLOGY IN NON‐DEMENTED INDIVIDUALS
Author(s) -
Lindberg Olof,
Mårtensson Gustav,
Stomrud Erik,
Wahlund LarsOlof,
Westman Eric,
Hansson Oskar
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2397
Subject(s) - subiculum , atrophy , hippocampus , psychology , pathology , dementia , hippocampal formation , posterior cortical atrophy , neuroscience , episodic memory , medicine , cognition , disease , dentate gyrus
atlas was also drawn manually. Results: In preliminary work, we found that using the template with SPM12 provided improved segmentations, specifically in individuals with large ventricles and extensive brain atrophy. Conclusions:We created a template suitable for studies with a wide range of ages and disease states throughout the adult lifespan ages 30+. The template, tissue probability maps, and related atlases are being made publically available to the research community for non-commercial use. Future studies will elucidate the improvement in MRI quantitation in comparison to existing templates.