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[IC‐P‐115]: COMPREHENSIVE MORPHOMETRIC CORTICAL/SUBCORTICAL NORMATIVE DATA: FREESURFER ATLASES COMPARISON
Author(s) -
Potvin Olivier,
Dieumegarde Louis,
Duchesne Simon
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2389
Subject(s) - normative , magnetic resonance imaging , ex vivo , alzheimer's disease neuroimaging initiative , nuclear medicine , medicine , psychology , disease , cognitive impairment , radiology , in vivo , biology , philosophy , microbiology and biotechnology , epistemology
Participants displaying the highest baseline SB (upper quartile) showed a large effect (hp1⁄4.308) of exercise on cBF. Conclusions: Six months of an individualized incremental exercise program resulted in improved CRF, increased PA and decreased SB compared with controls. There were no differential group effects in cBF; however, amongst highly sedentary participants those in the exercise group displayed increased cBF while the control group exhibited decreased cBF at follow-up. Our results suggest that highly sedentary adults in the preclinical stage of AD enrolled in an exercise program may experience improved cBF in regions known to decline with age and AD.More robust findings may have been precluded by the fact that the trial enrolled adults above the targeted activity level. These findings can be used to inform exercise prescription as our protocol had large effects on three primary modifiable outcomes that are associated with risk for AD and displayed favorable effects on cBF in participants exhibiting high sedentary behavior.