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[IC‐P‐110]: GREY MATTER CONNECTIVITY IS RELATED TO A STEEPER LOSS OF MEMORY AND LANGUAGE FUNCTIONING OVER TIME IN PATIENTS WITH SUBJECTIVE COGNITIVE DECLINE
Author(s) -
Verfaillie Sander C.J.,
Slot Rosalinde E.R.,
Dicks Ellen,
Prins Niels D.,
Overbeek Jose M.,
Scheltens Philip,
Barkhof Frederik,
Flier Wiesje M.,
Tijms Betty M.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2384
Subject(s) - grey matter , betweenness centrality , neuropsychology , cognition , psychology , episodic memory , cognitive decline , effects of sleep deprivation on cognitive performance , audiology , dementia , centrality , medicine , neuroscience , magnetic resonance imaging , disease , white matter , statistics , mathematics , radiology
structural brain measures than with AV1451 uptake. Perhaps atrophy provides a tighter link with cognitive decline than tau pathology, possibly because NFTs precede the neurodegeneration which produces cognitive impairment and/or because tau pathology does not capture other contributors to loss of neuronal integrity. The more complementary relationship of AV1451 uptake and structural MRI 5may reflect that in early AD tangle pathology is the primary driver of neuronal integrity in this region, as opposed to language and executive networks.