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[IC‐P‐109]: REGIONAL AV1451 UPTAKE AND CORTICAL THICKNESS IN RELATION TO MEMORY, LANGUAGE AND EXECUTIVE FUNCTIONING IN AMYLOID‐POSITIVE SUBJECTS
Author(s) -
Wisse Laura E.M.,
Das Sandhitsu R.,
Xie Long,
Ittyerah Ranjit,
Yushkevich Paul A.,
Wolk David A.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2383
Subject(s) - dementia , psychology , cognition , temporal lobe , neuroscience , recall , effects of sleep deprivation on cognitive performance , semantic memory , audiology , medicine , disease , cognitive psychology , epilepsy
regressing each person’s memory performance on their subjective memory ratings. Age, gender, education and depression scores were controlled for in each statistical model. Results: Increased EC Tau was associated with significantly lower volumes in all HCsf except for CA2/3 where it was trending (p1⁄4.075). Increased EC Tau was also associated with decreased memory awareness r1⁄4-0.5, p<.001. Of the HCsf only the subiculum (r1⁄40.4, p<.001) and CA1 (r1⁄40.3, p1⁄4.004) demonstrated a significant association, such that lower volume was associated with decreased memory awareness. Last, subiculum volume was found to partially mediate the relationship between EC Tau and memory awareness (bias-bootstrapping 95% BCI, [-0.63,-0.02]), Sobel test t1⁄4-2.1, p1⁄4.036 (Fig.1). None of the other HCsf showed a significant mediation effect. Conclusions: These results suggest strong links among EC tau burden, HCsf subfields and memory awareness, and highlight the involvement of MTL regions in anosognosia. Furthermore, decreased memory awareness may be caused by tau-induced subiculum volume loss in a group of individuals with varying degrees of memory impairment. Future work should examine the interplay between amyloid pathology and these MTL neurodegenerative measures for memory awareness.