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[IC‐P‐103]: APPLICATION OF A MULTI‐ATLAS SEGMENTATION TOOL TO HIPPOCAMPUS, VENTRICLE, AND WHOLE BRAIN SEGMENTATION
Author(s) -
Wang Xue,
Ghayoor Ali,
Novicki Andrew,
Holmes Sean,
Seibyl John,
Hesterman Jacob
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2377
Subject(s) - segmentation , computer science , neuroimaging , hippocampus , artificial intelligence , minimum bounding box , brain size , magnetic resonance imaging , medicine , nuclear medicine , radiology , psychiatry , image (mathematics)
VEGF and Tie2 measurements were included (n1⁄41877, age 4668, 54% women). Mean interval between blood draw and MRI was 1.560.77 years. MRI volumetric measurements of gray (GM) and white matter, white matter hyperintensity (WMH), and cerebrospinal fluid were regressed onto total intracranial volumes to account for differences in head sizes, and the residuals of each regression were used as outcomes in separate models. VEGF and Tie2 were log-transformed to normalize the distributions and were analyzed in SDU as predictors. All analyses were adjusted for age, age, sex, time between blood draw and MRI, waist-tohip ratio, systolic blood pressure, hypertension treatment, diabetes mellitus, current smoking, and prevalent cardiovascular disease. Results:Higher circulating VEGF levels were associated with lower hippocampal volume (Estimate by standard deviation units 6 se1⁄4 -0.0760.03, p1⁄40.041). Higher Tie2 levels were associated with lower total brain (-0.0760.02, p1⁄40.001) and cortical GM (-0.0660.02, p1⁄40.008) volumes, and with higher WMH volume (0.0460.01, p1⁄40.001). Conclusions: Our results suggest that increased levels of VEGF and Tie2 are associated with early gray matter loss and white matter disease in young and middle-aged adults, independent of the effects of vascular risk factors and cardiovascular disease. These preliminary findings suggest a role of growth factors in early brain changes that are observed in small vessel disease and Alzheimer’s disease. We plan to expand these findings by relating vascular growth factors to cognitive function, and with Mendelian randomization analyses.