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[IC‐P‐102]: CIRCULATING VEGF AND STIE2 AND MRI FINDINGS IN YOUNG AND MIDDLE‐AGED ADULTS IN THE FRAMINGHAM HEART STUDY
Author(s) -
Raman Mekala R.,
Himali Jayandra J.,
Conner Sarah C.,
DeCarli Charles S.,
Vasan Ramachandran S.,
Beiser Alexa S.,
Seshadri Sudha,
Satizabal Claudia L.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2376
Subject(s) - medicine , framingham heart study , cardiology , vascular endothelial growth factor , hyperintensity , angiopoietin receptor , blood pressure , framingham risk score , angiogenesis , white matter , magnetic resonance imaging , disease , radiology , vegf receptors
Background: Impairment in activities of daily living (ADL) is a fundamental feature of Alzheimer’s disease (AD). This study explores correlation between cognitive and functional impairment and grey matter (GM) volumes in people with mild cognitive impairment (MCI) and AD. Methods: 78 patients with amnestic MCI (N1⁄444) and AD (N1⁄434) from a community memory clinic underwent clinical assessment and magnetic resonance imaging. T1-weighted images were obtained using the Siemens Avanto 1.5 T scanner and pre-processed with SPM12 VBM pipeline. The variables of interest (cognitive and functional impairment) were measured using the Addenbrooke’s cognitive examination-revised (ACE-R) and Bristol activities of daily living (BADL). All comparisons were adjusted for age and gender. The statistical analysis was carried out in SPM12. Results:See table 1 for demographic, cognitive and functional data. GROUPCOMPARISONAs predicted, AD patients showed widespread areas of GM tissue loss compared to MCI, particularly in medial-temporal and parietal areas (Fig.1). CORRELATION WITH ACE-R GM was correlated positively with ACE-R in anterior and posterior cingulate, supramarginal/ angular gyrus, parahippocampal gyrus (p<0.001) (Fig.2). The following clusters were statistically significantly associated applying family-wise error (FWE) correction at cluster level: middle/inferior temporal gyrus (p<0.001), temporo-occipital cortex near fusiform gyrus (p1⁄4<0.001), frontal pole/anterior cingulate and right hippocampus/parahippocampal gyrus (p<0.001) CORRELATION WITH BADL GM was correlated negatively with BADL in frontal and parietal areas, and in the left thalamus. The strongest correlations were in the frontal pole (bilaterally) and the right opercular/insular cortex (although they only approached