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[IC‐P‐100]: MOVING AWAY FROM SINGLE AD‐SIGNATURE ROI: ASSESSING THE RELATIONSHIP BETWEEN WHOLE‐BRAIN GRAY MATTER PATTERN, AD PATHOLOGY, AND COGNITION IN HEALTHY ELDERLY AT RISK OF AD
Author(s) -
Binette Alexa Pichet,
VachonPresseau Étienne,
La Joie Renaud,
Poirier Judes,
RosaNeto Pedro,
Collins Louis,
Breitner John C.S.,
Villeneuve Sylvia
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2373
Subject(s) - atrophy , psychology , cognition , correlation , dementia , neurodegeneration , hippocampal formation , neuroscience , medicine , pathology , audiology , disease , mathematics , geometry
controlling for age, gender, and education. Additionally, intracranial volume and scan type were controlled for MRI. FDR/ FWE correction for multiple comparisons was applied. Results: The EOAD sample had mean age of 64.265.4 years, education of 16.162.8 years and MMSE 25.662.9. There were 49% male and 67% APOE ε4 carriers. Scree plot using the pseudo T-squared suggested a 4-cluster solution (see Table 1). Cluster 1 (N1⁄464) showed a memory-predominant impairment and neurodegenerative changes (FDG>MRI) in the medial and lateral temporal, lateral parietal and posterior cingulate (see Figures 1 and 2). Cluster 2 (N1⁄431) showed impaired memory