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[IC‐P‐083]: CLUSTERING AND SWITCHING INDICES OF VERBAL FLUENCY TASKS AND THEIR FUNCTIONAL NEUROANATOMICAL CORRELATES IN MILD COGNITIVE IMPAIRMENT
Author(s) -
Chu Kyungjin,
Yi Dahyun,
Byun Min Soo,
Lee Jun Ho,
Lee Dong Young
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2356
Subject(s) - fluency , verbal fluency test , audiology , neuropsychology , psychology , task (project management) , cluster size , cognition , cluster analysis , voxel , medicine , cognitive psychology , neuroscience , artificial intelligence , computer science , radiology , electronic structure , mathematics education , management , physics , quantum mechanics , economics
memory performance was the basis for the beliefs concerning memory. Methods: A total of 85 cognitively-normal adults (ages 33-93) from the Dallas Lifespan Brain Study completed Florbetapir PET imaging and the Metamemory in Adulthood questionnaire. Subscales included evaluation of memory capacity, change/stability, anxiety, achievement, locus of control, task, and strategy. In a first step, mean cortical SUVRwas used to predict subjective memory scores, after controlling for age and gender. In a second step, mediation analyses assessed whether the amyloid effects were mediated by actual memory performance using a composite of four episodic memory indicators. Results: Higher mean cortical SUVR was associated with beliefs of lower capacity (Figure 1), lower stability/greater change (Figure 2), and greater anxiety (Figure 3). Importantly, participants’ beliefs about their memory was validated by the finding that actual memory performance mediated the relationship of amyloid to beliefs about memory capacity (Figure 4) and memory-related anxiety (Figure 5). Conclusions:By utilizing a multi-dimensional subjective memory questionnaire, our results demonstrate the importance of asking a broader range of questions about an individual’s knowledge, perception and beliefs about their own memory to properly address the consequences of amyloid deposition for subjective memory. Our results clearly demonstrate that amyloid-associated beliefs about memory capacity as well as memory-related anxiety are mediated by actual performance in memory.