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[IC‐P‐080]: USEFULNESS AND STABILITY OF MULTICENTER DIFFUSION TENSOR IMAGING AS AN EARLY MARKER FOR SUBJECTIVE COGNITIVE DECLINE AND AMNESTIC MILD COGNITIVE IMPAIRMENT: FIRST RESULTS FROM THE PROSPECTIVE DZNE DELCODE STUDY
Author(s) -
Brueggen Katharina,
Dyrba Martin,
CardenasBlanco Arturo,
Jessen Frank,
Duzel Emrah,
Spottke Annika,
Nestor Peter,
Buerger Katharina,
Schneider Anja,
Peters Oliver,
Priller Josef,
Wiltfang Jens,
Laske Christoph,
Teipel Stefan J.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2353
Subject(s) - diffusion mri , dementia , fractional anisotropy , cognitive decline , medicine , prospective cohort study , audiology , psychology , grey matter , cardiology , white matter , magnetic resonance imaging , disease , radiology
heterogeneous, being associated with all four subtypes, but predominantly the frontotemporal and subcortical subtypes. Conclusions:We demonstrate the use of a probabilistic generative model of disease subtypes to characterise genetic FTD heterogeneity. Our results provide new insights into the phenotypic variability in the C9orf72 mutation, revealing that this group consists neuroanatomically of two major subtypes. Further studies will be required to understand how these map on to the underlying clinical syndromes and pathology.