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[IC‐P‐073]: CEREBRAL 18F‐FLUORODEOXYGLUCOSE‐POSITRON EMISSION TOMOGRAPHY IN PROLONGED DELIRIUM
Author(s) -
Pion Caroline Malo,
Nehme Jessica,
Filion Josée,
Desmarais Philippe,
Masson Hélène,
Bruneau MarieAndrée,
Soucy JeanPaul
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2346
Subject(s) - delirium , dementia , medicine , neuroimaging , positron emission tomography , disease , pediatrics , psychiatry , radiology
Background:Defined as tightened high convexity, enlarged sylvian fissures, and ventriculomegaly, disproportionately enlarged subarachnoid hydrocephalus (DESH) is an imaging phenotype of idiopathic normal pressure hydrocephalus (iNPH) that increases in prevalence with advancing age. The objective of this study was to automate detection of key features of DESH to provide a tool to investigate CSF dynamics with aging.Methods:The FLAIR images of 1594 subjects were visually assessed by a neurologist for tightened high convexity, ventriculomegaly, enlarged sylvian fissures, and entrapped fluid in sulci. These four features constituted “observation classes” in our study. To create the automatic detector, a probabilistic atlas of 123 sulcal regions was obtained, then deformed to the T1-weighted MRI images of each subject (Figure 1). Estimates of CSF volume per sulcal region were obtained from the overlap of SPM-based segmentation and the warped atlas and normalized by individual intracranial volume. An area under