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[IC‐P‐067]: DIAGNOSTIC UTILITY OF FDG‐PET TO CONFIRM A CLINICAL SUSPICION OF AMYOTROPHIC LATERAL SCLEROSIS
Author(s) -
Altomare Daniele,
Orini Stefania,
Agosta Federica,
Sarasso Elisabetta,
Festari Cristina,
Filippi Massimo,
Boccardi Marina
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2340
Subject(s) - medicine , amyotrophic lateral sclerosis , context (archaeology) , critical appraisal , neuroimaging , gold standard (test) , pathology , psychiatry , disease , paleontology , alternative medicine , biology
that AD family history (FH) changes the association between VL poly-T length and cognitive decline in cognitively normal middle-aged and aged adults across the AD spectrum. Thus, we examined TOMM40 poly-T genotype, FH, and their interaction on changes in medial temporal lobe (MTL) gray matter (GM) and glucose metabolism across time. Methods:Longitudinal linear mixed modeling assessed FH and TOMM40 main effects and interactions, among non-APOE4’s, for subsets of 913 middle-aged subjects from the Wisconsin Registry for Alzheimer’s Prevention (WRAP) over 7-10 years and 334 subjects from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) over 3 years. FreeSurfer was used to derive mean MTL volume and cortical thickness (CT). Arterial spin labeling (ASL) in WRAP and fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in ADNI were used to gauge MTL glucose metabolism. Results: Significant TOMM40 x FH interactions indicated that TOMM40 VL’s who were FHand FH+ respectively showed robust step-wise protective or detrimental effects for GM, ASL, and FDG-PET. Figure 1 and Figure 2 illustrate this association in MTL volume for WRAP and MTL CT for ADNI. Figure 3 illustrates this association for MTL versus global cerebral blood flow in WRAP, with comparable associations seen for FDG-PET in ADNI. Conclusions: Findings in both late middle-aged and aged cohorts suggest that FH strongly modulates the association of TOMM40 VL genotype over time on regional brain volume and glucose metabolism indices. These results extend previous findings on cognitive decline and may clarify discrepancies in the TOMM40 ‘523 poly-T literature.