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[IC‐P‐060]: THE INFLUENCE OF APOE GENOTYPE ON PATTERN SEPARATION IN THE HUMAN DENTATE GYRUS
Author(s) -
Lee Hwee Ling,
Heise Verena,
Brenner Daniel,
Stirnberg Ruediger,
Stoecker Tony,
Montag Christian,
Jung Sonja,
Axmacher Nikolai
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2333
Subject(s) - dentate gyrus , entorhinal cortex , apolipoprotein e , hippocampal formation , psychology , neuroscience , hippocampus , temporal lobe , medicine , pathology , disease , epilepsy
Statistical analyses were performed separately in the two cohorts, assessing both ε4-related differences on global cortical uptake and conducting voxelwise analyses. Results: In the whole cognitively normal group, ε4 was associated with higher cortical PIB but not AV1451-SUVR (Fig 1a). Voxelwise analyses showed that ε4 was associated with higher PIB-SUVR in the entire cortex (Fig 1b). AV1451-uptake was increased in ε4 carriers in the temporal lobe, but this effect was not significant after controlling for PIB status or SUVR (Fig 1c). In patients, the presence of the ε4 allele was not associated with significant differences in global measures of AV1451 or PIB-SUVR (Fig 2a). Voxelwise analyses showed no difference on PIB-PET, while ε4 carriers had higher AV1451uptake in the anterior medial temporal lobe (MTL); that difference remained unchanged when controlling for PIB-SUVR (Fig 2b). In ε4-carriers, AV1451-uptake in the MTL was associated with lower performances in delayed recall, but not other cognitive tests (Fig 2c). Conclusions: In cognitively normal individuals, the effect of APOE ε4 on tau pathology seems to be driven by the effect of ε4 on Ab deposition. However, when assessing amyloid-positive