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[P1–164]: AGE MODERATES EFFECTS OF PICALM RS541458 ON COGNITIVE IMPAIRMENT AND BRAIN STRUCTURE AND FUNCTIONS
Author(s) -
Liu Zhen,
Zhang Zhanjun
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.231
Subject(s) - middle frontal gyrus , neuropsychology , resting state fmri , psychology , cognition , lingual gyrus , functional magnetic resonance imaging , medial frontal gyrus , neuroscience , executive functions , audiology , medicine
global SUVR was moderate (0.29), and that for ROIs ranged from 0.0 to 0.44, after correcting for age and sex (Table). The correlations between SUVR in different brains were high (0.58 to 0.86). Using 1.5 SUVR as the cut-off, 6/60 (10%) (2 MZ and 4 DZ) were positive; all were discordant with their co-twins. SUVR increased with age, and was significantly correlated with global cognition, memory and attention/processing speed, but not with vascular risk factors. Conclusions: Amyloid load in the brains of cognitively normal older people has moderate heritability with suggestion of strong environmental influences. A larger study (currently ongoing) will help interrogate some of these factors.