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[IC‐P‐032]: TRAUMATIC BRAIN INJURY EFFECTS UPON THE STRUCTURAL CONNECTOME MIRROR THOSE CAUSED BY ALZHEIMER's DISEASE
Author(s) -
Irimia Andrei,
Torgerson Carinna M.,
Van Horn John D.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2304
Subject(s) - traumatic brain injury , tractography , white matter , diffusion mri , connectome , magnetic resonance imaging , medicine , neuroscience , psychology , functional connectivity , psychiatry , radiology
cortical atrophy (PCA) is an uncommonAD variant presenting with progressive visuospatial symptoms, and the relationships between functional networks in PCA are unknown. We hypothesized that PCA patients would show early decreased integrity within the visual network, with corresponding increases in SN connectivity, despite relative preservation of DMN. As the medial and lateral pulvinar are anatomically interconnected with SN, DMN, and visual structures, we further hypothesized that the pulvinar nucleus might play a key role in these networks. Methods: 26 individuals diagnosed with PCA (all amyloid-positive or with AD-consistent CSF) and 64 matched controls were recruited through UCSFMemory and Aging Center research programs. Each completed a standardized neuropsychological battery, structural imaging, and task-free fMRI. We used voxel-based morphometry (VBM) to assess structural atrophy. For fMRI, time series from seeds for networks of interest were regressed across the whole brain and fitted to a second-level regression model for group effects analysis. Functional data analyses were atrophy-corrected using the BPM toolbox. Results: PCA patients show relatively preserved memory in the early stages of illness despite poor visuospatial performance; like others with AD, they also show preserved social sensitivity. As expected, VBM revealed highly significant parieto-occipital atro-