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[IC‐P‐023]: CEREBRAL PERFUSION IN THE 5XFAD MOUSE MODEL OF ALZHEIMER's DISEASE
Author(s) -
DeBay Drew R.,
Phi TanTrao,
Bowen Chris V.,
Burrell Steve,
Darvesh Sultan
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2295
Subject(s) - perfusion , cerebral blood flow , medicine , neuroimaging , perfusion scanning , neuroscience , alzheimer's disease , positron emission tomography , cerebral perfusion pressure , spect imaging , pathology , disease , nuclear medicine , psychology
assessed in the Y-maze. In vivo signals were confirmed by autoradiography and immunohistochemistry in brain sections from scanned mice. Results:A progressive, age-dependent reduction in F-BCPP-EF uptake was observed in hippocampal and forebrain regions of tauTg mice, coinciding with the development of tau lesions detected by C-PBB3 PET. A strong association was observed betweenMC-I signals detected by PET, hippocampal volume assessed byMRI, and learning andmemory performance in the Y-maze task. In vivo findings were confirmed by F-BCPP-EF autoradiography and immunohistochemistry for AT-8 (tau phosphorylation), GFAP (astrocytes), IBA-1 (microglia), NeuN (neurons). Conclusions:MC-I PET may provide a useful non-invasive imaging biomarker for the real-time identification of early-stage mitochondrial abnormalities associated with tau-induced neurodegenerative cascades.