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[IC‐P‐020]: RELATIONSHIP OF PHYSICAL ACTIVITIES DURING YOUNG ADULTHOOD AND MIDLIFE WITH BRAIN AMYLOID DEPOSITION, GLUCOSE METABOLISM, AND CORTICAL THICKNESS IN LATE LIFE
Author(s) -
Sohn Bo Kyung,
Yi Dahyun,
Byun Min Soo,
Choe Young Min,
Kim Jee Wook,
Choi Hyo Jung,
Baek Hyewon,
Lee Jun Ho,
Kim Hyun Jung,
Kim Shin Gyeom,
Seo Eun Hyun,
Han Ji Young,
Woo Jong Inn,
Lee Dong Young
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2292
Subject(s) - precuneus , dementia , entorhinal cortex , positron emission tomography , atrophy , psychology , pittsburgh compound b , posterior cingulate , cognitive decline , standardized uptake value , neurodegeneration , superior parietal lobule , medicine , neuroscience , hippocampus , cortex (anatomy) , disease , cognition
B-spline resample each PET scan to the T1-SST space for each timepoint’s SUVR calculation. We hypothesized that our approach (using a single mean-space T1-weighted image for segmentation and region localization, and a groupwise alignment of PET images with a single rigid registration to the mean-space T1) would yield improved longitudinal measurement performance compared to traditional intra-timepoint measurement methods. Our metrics of evaluation were: (1) reliability (larger Rof linear intra-subject fits) and (2) plausibility (smaller percent of subjects with significantly negative slopes, indicating biologically-implausible decreasing amyloid) of intra-subject serial trajectories. We tested this hypothesis using scans of 128 Mayo Clinic study participants with 3 serial timepoints with MRI and PiB scans with baseline PiB SUVR 2.5 (and consequently expected non-decreasing amyloid trajectories). Results: Compared to the traditional cross-sectional method, the proposed longitudinal pipeline showed increased reliability of PiB-PET SUVR measures when using 6/7 tested reference regions. The percentage of subjects with biologically-implausible decreasing slopes using the longitudinal method was also that of the traditional method when using 6/7 tested reference regions. Conclusions: Our proposed automated longitudinal pipeline measuring PiB-PET SUVR by simultaneously processing serial scans produces measurements with improved reliability and plausibility compared to traditional intra-timepoint methods.