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[IC‐P‐019]: EFFECTS OF USING A NOVEL LONGITUDINAL PROCESSING PIPELINE FOR MEASURING CHANGE OVER TIME IN PIB‐PET
Author(s) -
Schwarz Christopher G.,
Gunter Jeffrey L.,
Lowe Val,
Vemuri Prashanthi,
Senjem Matthew L.,
Petersen Ronald C.,
Knopman David S.,
Jack Clifford R.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2291
Subject(s) - image registration , artificial intelligence , segmentation , nuclear medicine , computer science , mathematics , pattern recognition (psychology) , medicine , image (mathematics)
interaction; F1⁄45.38, p1⁄40.03). APOE-ε4 carriers had lower NAA/ mI compared to non-carriers (t1⁄42.24, p1⁄40.03). tCho/Cr in white matter was associated with Aß (r1⁄4 -0.53 p1⁄40.004) and WMH (r1⁄4 -0.51; p1⁄40.006); APOE-ε4 carriers with high WMH showed strongest reductions of tCho/Cr (significant APOE-ε4 x WMH interaction, F1⁄46.45, p1⁄40.02). Conclusions:These findings suggest that a neurometabolic signature of AD, defined by metabolic correlates of Aß and APOE-ε4 in older adults, consists of reduced NAA/mI in gray matter and reduced tCho/Cr in white matter. We speculate that these metabolic differences reflect neuronal impairment, glial activation, and altered choline metabolism. This neurometabolic signature of AD is also associated with WMH, both independently and synergistically with Aß and APOE-ε4, emphasizing the importance of small-vessel cerebrovascular disease for AD pathogenesis.