Premium
[IC‐P‐016]: INVESTIGATING THE CLINICAL IMPACT OF [ 18 F]FLUTEMETAMOL PET IN A TERTIARY MEMORY CLINIC SETTING IN PATIENTS WITH UNCERTAIN DIAGNOSIS
Author(s) -
Leuzy Antoine,
Chiotis Konstantinos,
Jelic Vesna,
Andersen Pia,
Friman Jennifer,
Lilja Johan,
Savitcheva Irina,
Nordberg Agneta
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2288
Subject(s) - medicine , dementia , memory clinic , medical diagnosis , neuropsychology , disease , pathology , psychiatry , cognition
60-90, who participated in the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE), were included in this study. All the subjects underwent comprehensive clinical and neuropsychological assessment, 11C-labelled Pittsburgh Compound B (PiB) positron emission tomography (PET), and Brain Magnetic resonance imaging(MRI). Mean cortical thickness values were obtained from AD-signature regions including the entorhinal, inferior temporal, middle temporal, and fusiform gyrus. BMI values for past lifetime periods((i.e., young adulthood: 20-30s and midlife: 40-50s) were calculated from self-recalled body weight and height, and current BMI was calculated from measured body weight and height. Multiple regression analyses were performed controlling age, gender, APOE e4 carrier status, and vascular risk scores. Results: For the overall subjects, past BMI, BMI at young adulthood in particular, was negatively associated with global cerebral Ab deposition, while current BMI was not. In contrast, current BMI showed significant positive association with AD-signature region cortical thickness, while past BMI did not. When subgroup analyses were performed for each gender, very similar relationships between lifetime BMIs and Ab deposition and cortical thickness were still found for males, whereas no significant association was observed between the variables for females. Conclusions: Our results suggest that relatively low past