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[IC‐P‐010]: SLEEP DISORDERED BREATHING, APOE4 AND β‐AMYLOID DEPOSITION IN COGNITIVELY NORMAL ELDERLY
Author(s) -
Shim Amanda,
Hogan Megan,
Halldin Kathryn,
Clark Hannah,
Behrens Beka,
Griffith Cassidy,
UmasaborBubu Ogie Queen,
Bubu Omonigho Michael
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2282
Subject(s) - medicine , linear regression , body mass index , cohort , apolipoprotein e , sleep disordered breathing , audiology , disease , cardiology , statistics , obstructive sleep apnea , mathematics
Background:Cross sectional analysis has shown an association between OSA severity and Ab burden using amyloid-PET, globally and regionally in the precuneus among MCI patients. However, whether OSA accelerates longitudinal increases in Ab burden in MCI patients is presently unclear. Methods: Study participants included a total of 798 subjects with a diagnosis of MCI and were a subset of the ADNI cohort (adni.loni.usc.edu). OSA was self-reported and participants were labeled either as OSA+, or OSA . Ab burden was determined by florbetapir SUVRs calculated by averaging across the 4 cortical regions and dividing this cortical summary ROI by a composite reference region. Mean and variance of the Ab data at each time point by OSA status were determined. To test whether OSA is associated with the rate of change in Ab data longitudinally, SAS PROC MIXED was used to fit the model with randomly varying intercepts and slopes allowing dependence on OSA status. The final model was adjusted for sex, body mass index and CPAP use status since there was no difference between OSA groups for APOE e4 status, age and history of cardiovascular disease.Results:At baseline, therewas significant variation between subjects in mean Ab-42 volumes (intercept) (mean SUVR; B 1⁄4 0.0008, Z-value 1⁄411.02, p < .0001). A significant variation in the change (slope) in Ab-42 volumes over time was also seen (mean SUVR; B 1⁄4 0.0084, Z-value 1⁄411.63, p < .0001). The covariance between the baseline Ab-42 level and Ab-42 volume change over time indicated that SDB subjects experienced a faster increase in brain Ab-42 volumes over time (p < .0001). The rate of change in Ab-42 deposition also varied significantly across OSA groups over the follow-up period. Conclusions: Obstructive Sleep Apnea possibly facilitates longitudinal increases in amyloid burden in elderly Mild Cognitive Impairment individuals. Further research examining mechanisms underlying effects of OSA on the longitudinal increases in Ab burden is needed.