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[P4–356]: ETHNICITY AND ALZHEMIER'S DISEASE: LESSONS FROM A LARGE COMMUNITY‐BASED CLINICOPATHOLOGICAL SERIES FROM BRAZIL
Author(s) -
Grinberg Lea T.,
Suemoto Claudia K.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2227
Subject(s) - dementia , ethnic group , confounding , disease , demography , population , gerontology , medicine , pathology , environmental health , sociology , anthropology
Background:Neurodegenerative disease is one of the main contributing factors affecting muscle atrophy. However, this intriguing brain-muscle axis has been explained by the unsubstantial mechanisms. Recently, there have been several studies that have evaluated the muscle profile and its relation to cognition in dementia patients; however, there is still lack of data using standardized methods and only few published studies on Asian populations. The objective of this study is to evaluate the relationship of muscle mass and strength to cognition in dementia patients with Alzheimer’s disease (AD). Methods: We recruited 91 dementia patients with probable AD without weakness. We assessed patients’ basic demographic characteristics, vascular risk, and global cognitive assessment scores. Muscle mass was measured using body dual energy X-ray absorptiometry, and two parameters were used to quantify the total body appendicular skeletalmusclemass (ASM): Index 1, theASMdivided by height squared, and Index 2, the ASM as a percentage of body weight. Muscle strength was assessed by isokinetic knee extensor MS using an isokinetic device at an angular velocity of 60 /s in nm/kg. Results: In both groups, the MM and MS were not related to each other. Only MS, but not MM, was negatively related to cognition. After adjusting for covariates, the relationship between MS and cognition was still remained in male group, however, was attenuated in female group. Conclusions: In patients with Asian AD dementia, the person with large muscles is not strong. Furthermore, the simple lower extremity MS assessment is more effective in predicting cognition than a MM measure in male patients. We can expect that interventions that focus on augmenting MS rather than MM will potentially help dementia patients maintain cognition.