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[P4–344]: HEARING LOSS AND RISK OF INCIDENT COGNITIVE IMPAIRMENT AND DEMENTIA: A META‐ANALYSIS OF COHORT STUDIES
Author(s) -
Gonzales Sergi Costafreda,
Proctor Danielle,
Mandavia Rishi,
Evans Hannah,
Goman Adele M.,
Lin Frank R.,
Livingston Gill,
Schilder Anne
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2214
Subject(s) - dementia , medicine , meta analysis , relative risk , cohort study , hearing loss , cohort , cognitive decline , prospective cohort study , risk factor , cognition , audiology , hazard ratio , confidence interval , psychiatry , disease
mild cognitive impairment (MCI) report diverging results (Vyhnalek et al., 2015; Djordjevic et al., 2008). Especially large population based studies examining age and sex differences are scarce (Wilson et al., 2007; Liang et al., 2016). The aim of our study was to examine the sexand age-specific associations of olfactory function and MCI in a well characterized German population based study sample. Methods: We compared 230 men (68.567.2 years) and 273 women (68.267.2 years) with MCI diagnosed according to Petersen’s criteria (Winblad et al., 2004) with 2118 cognitively normal participants (68.567.2, 49%men) from the third examination of the Heinz Nixdorf Recall Study (2010-2016). Participants underwent Sniffin’ Sticks Screening Test measuring olfactory function on a scale of 0-12 points, where higher scores indicate better performance. Further they performed a cognitive screening consisting of eight tests (eight wordlist immediate/delayed recall, labyrinthtest, naming animals, clock-drawing test, trail-making test A/B, stroop task). To examine the association of olfactory function (linear, rescaled for analysis) with MCI (yes/no), we performed logistic regression models stratified by age-group (young-age: 64 years; middle-age: 65-74 years; old-age: 75 years) and gender (odds ratio (OR), 95% confidence interval (CI)). All regression models were performed unadjusted as well as adjusted for age, education and smoking status. Results:Descriptive analyses of olfactory function showed lower mean scores for men withMCI (8.6862.0) compared to women with MCI (8.9962.1). Similar trend is found in cognitively normal patients (men:8.9961.9, women:9.4361.8). The regression analysis showed an association between olfactory performance andMCI inmiddle agedwomen only (adjustedOR1⁄41.20, CI 1.07-1.36). We found no associations for the young-age group (OR1⁄40.99; CI 0.86-1.14) or old-age group (OR1⁄41.06; CI 0.941.18) in women. There were no associations found in men (young-age: OR1⁄41.06, CI 0.91-1.23; middle-age: OR1⁄41.06, CI 0.94-1.19; old-age: OR1⁄41.04, CI 0.92-1.18). Conclusions: In this study worse olfactory function appears to be associated with MCI in middle-aged women. This is the first study reporting on age and gender specific associations between olfactory function and MCI. Longitudinal studies are necessary to confirm these results.