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[P4–336]: ILLITERACY AND DYSLIPIDEMIA: RISK FACTORS FOR ALZHEIMER's DISEASE, BUT MARKERS OF BETTER CLINICAL EVOLUTION?
Author(s) -
Ferreira Frota Norberto Anizio,
Lima Fabricio Oliveira,
Lauana Lima Silva Vanessa,
Alves Gisele Collyer,
Rabelo de Brito Mariana,
Albuquerque Flavia Timbó,
Mota Andreia Braga,
Costa e Silva Yasmin,
Correa Larissa Chagas,
Alves Vidal Lorena Chérida,
Carvalho de Queiroz Inessa
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2206
Subject(s) - functional illiteracy , medicine , logistic regression , dementia , cognition , mann–whitney u test , demography , dyslipidemia , disease , psychiatry , sociology , political science , law
as risk for cognitive impairment based on dual-task cost and adjusted for age, race, sex, and education. Additional adjustment by change in hippocampal volumes was conducted. Results: After 8 years, 40/76 participants were cognitively impaired (53%). Higher dual-task cost (e.g. greater decline in speed with addition of visual-spatial task) was associated with greater odds of cognitive impairment at 8 years, both before (OR per 1% increase in dual task cost1⁄41.08 (1.01, 1.15)) and after (OR1⁄41.08 (1.01, 1.16)) adjustment for demographics. Greater annualized decline in gray matter volume attenuated the association of dual task cost with cognitive impairment for both left (OR1⁄41.05 (0.85, 1.28)) and right (OR1⁄41.01 (0.94, 1.09)) hippocampus. Conclusions:In this group of high functioning older adults, greater declines in gait speed while dual-tasking predicted greater risk for cognitive impairment 8 years later. Faster hippocampal atrophy may be an important neurobiological correlate that could explain this association. Dual-task walkingmay serve as a stress test on central nervous system resources and could provide an early clinical indicator for increased dementia risk.