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[P4–276]: APOE GENOTYPE INFLUENCES HOW CEREBRAL BLOOD FLOW AND VASOREACTIVITY PREDICT NEUROPSYCHOLOGICAL DECLINE OVER AN 18‐MONTH FOLLOW‐UP: THE VANDERBILT MEMORY AND AGING STUDY
Author(s) -
Osborn Katie E.,
Neal Jacquelyn E.,
Liu Dandan,
Pechman Kimberly R.,
Badami Faizan,
Watchmaker Jennifer M.,
Gordon Elizabeth A.,
Cambronero Francis E.,
Gifford Katherine A.,
Hohman Timothy J.,
Donahue Manus J.,
Jefferson Angela L.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2145
Subject(s) - cerebral blood flow , neuropsychology , dementia , cognitive decline , psychology , cardiology , magnetic resonance imaging , effects of sleep deprivation on cognitive performance , cognition , medicine , neuroscience , disease , radiology
other groups, including sAD.Conclusions:Our results suggest a high frequency of microhemorrhages in DSAD cases in the occtx, more so than sAD. This along with the increased amount of CAA suggests that cerebrovascular pathology may be an under-recognized, yet significant contributor to aging and the development of dementia in peoplewith DS.We are currently in the process of quantifying microbleeds using MRI in the occtx in our aging DS cohort to link this pathology with cognitive decline. Funding from NIH/NICHD R01HD064993.