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[P4–274]: COMPARISON OF BINDING PROPERTIES OF THK5117, THK5351, PBB3 AND T807 IN AUTOPSIES OF ALZHEIMER DISEASE CASES
Author(s) -
Lemoine Laetitia,
Gillberg PerGöran,
Svedberg Marie,
Stepanov Vladimir,
Nag Sangram,
Tian He,
Higuchi Makoto,
Halldin Christer,
Nordberg Agneta
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2143
Subject(s) - human brain , in vitro , in vivo , chemistry , biochemistry , neuroscience , biology , microbiology and biotechnology
of interest between AD, CBD, and PSP (Table 2). However, pairwise comparisons using Tukey and Kramer test revealed a significant difference (p1⁄4 0.02) in the proportion of total neurons with ht-NCI between AD and CBD, with AD showing the lower proportion (Figure 1-2). We also detected a significant difference (p1⁄4 0.0023) in the proportion of orexin positive neurons with ht-NCI between AD and CBD, with AD showing the lower proportion (Figure 3-4). Conclusions:Our unbiased stereological investigation detected moderate to high accumulation of phospho-tau in PFN in all three tauopathies. Tau burden in orexinergic neurons show a clear distinction between AD and CBD. Quantitative characterization of tau pathology and neuronal loss in sleep-related nuclei may inform on neurobiological basis of sleep disturbances. Further studies should focus on the role of degeneration of orexinergic neurons in exacerbating sleep fragmentation in AD patients.