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[P4–244]: WHITE MATTER INTEGRITY REFLECTS TAU ACCUMULATION IN AD‐DEFINED REGIONS
Author(s) -
Strain Jeremy F.,
Smith Robert,
Beaumont Helen,
Gordon Brian A.,
Mishra Shruti,
Christensen Jon,
Morris John C.,
Benzinger Tammie L.S.,
Ances Beau M.
Publication year - 2017
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2017.06.2112
Subject(s) - white matter , diffusion mri , amyloid (mycology) , neuroscience , fractional anisotropy , positron emission tomography , psychology , atrophy , pathology , nuclear medicine , magnetic resonance imaging , medicine , radiology
AD(EOAD) presents the unique opportunity to isolate effects ofAD pathology in NPS onset, independent from cerebrovascular disease and other age-associated co-morbidities.Methods:We administered the Geriatric Anxiety Inventory to twenty-one cognitively normal subjects (28-42 years old) from the Colombian kindred: ten mutation carriers and eleven age-matched non-carriers. All subjects had one parent with the PSEN-1 mutation, and thus bore a 50% risk of carrying it themselves; all were blind to their genetic status. All subjects underwent amyloid (Pittsburgh Compound B) and tau (Flortaucipir a.k.a AV-1451) PET imaging. SCD was measured using theMemory Complaint Scale-Spanish version. Pearson correlations were used to compare anxiety, SCD, cortical amyloid, and regional tau levels in inferior temporal lobe (IT) and entorhinal cortex (EC).Results:InPSEN-1 carriers, greater anxiety was associated with greater cortical amyloid (r1⁄40.817, p1⁄40.004), but not with tau (IT: r1⁄4-0.007, p1⁄40.985; EC: r1⁄40.036, p1⁄40.921). Greater SCD (self and informant) was also associated with greater cortical amyloid (self: r1⁄40.902, p1⁄40.001), but not tau (IT: r1⁄40.076, p1⁄40.846; EC: r1⁄40.018, p1⁄40.963). There were no differences between mutation carriers and non-carriers in anxiety (p1⁄40.911) or SCD (self: p1⁄40.848; informant: p1⁄40.614). Among mutation carriers, greater anxiety was associated with greater SCD (self: r1⁄40.957; p<0.001; informant: r1⁄40.932; p1⁄4<0.001). Conclusions:Preliminary findings support a relationship between anxiety, SCD, and amyloid (but not tau), among mutation carriers from the Colombian kindred of EOAD. Results suggest that anxiety in this cohort is redundant with SCD, and related to early changes in AD biomarkers, years before the estimated onset of mild cognitive impairment. Future longitudinal studies with larger samples and in relation to objective cognitive measures are needed to better understand anxiety and SCD in preclinical AD. B-amyloid Regions Diffusivity Diffusivity Diffusivity Anisotropy